Potassium Fluoride → HCID 13537724, compound

Participants

Reaction Steps

By the method of M. Geisel and R. Mews (Chem. Ber. 115, 2135 (1982), incorporated herein by reference, 2.0 g (0.0088 mole) of 3-chloro-4-(3-methoxyphenyl)-1,2,5-thiadiazole (from Example 2) was heated with 2.04 g (0.035 mole) of potassium fluoride in 20 ml of sulfolane at 180° C. to produce 0.48 g of 3-fluoro-4-(3-methoxyphenyl)-1,2,5-thiadiazole, Compound 21 of Table I. Compounds 18-20 of Table I were also prepared by this method.

Provenance & Evidence