Potassium Fluoride → HCID 13537724, compound

HRID 1583963Notes

Reaction equation

HRID 1583963 reaction equation
Cl[C:2]1[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([O:13][CH3:14])[CH:8]=2)=[N:5][S:4][N:3]=1.[F-:15].[K+]>S1(CCCC1)(=O)=O>[F:15][C:2]1[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([O:13][CH3:14])[CH:8]=2)=[N:5][S:4][N:3]=1

Participants

4

Reactant 2

HCID 522689Potassium FluorideHCID 13537723HCID 13537723, compound

Product 1

HCID 13537724HCID 13537724, compoundYield 25.9%

Reagents, catalysts & solvents 1

HCID 31347SulfolaneSolvent

Procedure

By the method of M. Geisel and R. Mews (Chem. Ber. 115, 2135 (1982), incorporated herein by reference, 2.0 g (0.0088 mole) of 3-chloro-4-(3-methoxyphenyl)-1,2,5-thiadiazole (from Example 2) was heated with 2.04 g (0.035 mole) of potassium fluoride in 20 ml of sulfolane at 180° C. to produce 0.48 g of 3-fluoro-4-(3-methoxyphenyl)-1,2,5-thiadiazole, Compound 21 of Table I. Compounds 18-20 of Table I were also prepared by this method.

Sources & evidence

ORD record
ord-b86a56541b76463f9dab755b114b9589
Source dataset
uspto-grants-1985_11
Patent number
US04555521

Reaction notes

Loading…