HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → alpha-Amino(4-chlorophenyl)acetamide hydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | Ethyl 2-bromo-2-(4-chlorophenyl)acetate | HCID 228840 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | alpha-Amino(4-chlorophenyl)acetamide hydrobromide | HCID 13481123 | — |
Reaction Steps
By the method of T. Naito, et al., Chem. Pharm. Bull. 16, 544 (1968), incorporated herein by reference, 50.0 g (0.18 mole) of ethyl alpha-bromo-(4-chlorophenyl)acetate, 110 ml of concentrated ammonium hydroxide solution, and ammonia gas in 125 ml of ethanol were reacted to produce 20.0 g of alpha-amino(4-chlorophenyl)acetamide hydrobromide (m.p. 273°-280° C. dec.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04555521 |
| Source dataset | uspto-grants-1985_11 |
| ORD ID | ord-324fe712606444d6a98b1b2e7433371b |
| Source note | uspto-grants-1985_11 |