反应详情

By the method of T. Naito, et al., Chem. Pharm. Bull. 16, 544 (1968), incorporated herein by reference, 50.0 g (0.18 mole) of ethyl alpha-bromo-(4-chlorophenyl)acetate, 110 ml of concentrated ammonium hydroxide solution, and ammonia gas in 125 ml of ethanol were reacted to produce 20.0 g of alpha-amino(4-chlorophenyl)acetamide hydrobromide (m.p. 273°-280° C. dec.).