HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Hydrazinoethanol → 9-methoxypyrazolo[3,4,5-kl]acridine-2(6H)-ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Hydrazinoethanol | HCID 8017 | — |
| Reactant | 1-chloro-7-methoxy-4-nitro-10H-acridin-9-one | HCID 438231 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 9-methoxypyrazolo[3,4,5-kl]acridine-2(6H)-ethanol | HCID 136166594 | — |
Reaction Steps
A solution of 3.6 g of 2-hydroxyethyl hydrazine in 5 ml of methanol and 20 ml of THF was added over 1.5 hours to a mixture of 6.09 g of 1-chloro-7-methoxy-4-nitro-9(10H)-acridinone in 75 ml of methanol and 55 ml of THF, and the resulting suspension was stirred 20 hours at room temperature. The precipitate was collected and recrystallized from DMSO-methanol, providing 9-methoxypyrazolo[3,4,5-kl]acridine-2(6H)-ethanol, mp 275°-276° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04555572 |
| Source dataset | uspto-grants-1985_11 |
| ORD ID | ord-0f74f574a5d94196a58d345460816cd8 |
| Source note | uspto-grants-1985_11 |