HCID 86754366, compound → HCID 69830767, compound

Participants

Reaction Steps

A mixture of 5-[3-methoxy-4-(2-phenyl-4-thiazolylmethoxy)cinnamylidene]-2,4-oxazolidinedione (0.76 g), palladium-carbon (5%, 1.0 g) and tetrahydrofuran (THF) (100 ml) was subjected to catalytic hydrogenation under 1 atmospheric pressure at room temperature. The catalyst was filtered off, and the filtrate was concentrated under reduced pressure. The concentrate was subjected to column chromatography on silica gel. From the fraction eluted with chloroform-ethyl acetate (4:1), 5-[3-[3-methoxy-4-(2-phenyl-4-thiazolylmethoxy)phenyl]propyl]-2,4-oxazolidinedione (0.25 g, 32%) was obtained. Recrystallization of the product from ethyl acetate-hexane gave colorless prisms, m.p.96-97° C.

Provenance & Evidence