反应详情

A mixture of 5-[3-methoxy-4-(2-phenyl-4-thiazolylmethoxy)cinnamylidene]-2,4-oxazolidinedione (0.76 g), palladium-carbon (5%, 1.0 g) and tetrahydrofuran (THF) (100 ml) was subjected to catalytic hydrogenation under 1 atmospheric pressure at room temperature. The catalyst was filtered off, and the filtrate was concentrated under reduced pressure. The concentrate was subjected to column chromatography on silica gel. From the fraction eluted with chloroform-ethyl acetate (4:1), 5-[3-[3-methoxy-4-(2-phenyl-4-thiazolylmethoxy)phenyl]propyl]-2,4-oxazolidinedione (0.25 g, 32%) was obtained. Recrystallization of the product from ethyl acetate-hexane gave colorless prisms, m.p.96-97° C.

1. customwas subjected to catalytic hydrogenation under 1 atmospheric pressure at room temperature
2. filtrationThe catalyst was filtered off
3. concentrationthe filtrate was concentrated under reduced pressure
4. washFrom the fraction eluted with chloroform-ethyl acetate (4:1)