4-(Chloromethyl)-5-methyl-2-phenyl-1,3-oxazole → 5-[2-[4-(5-Methyl-2-phenyl-4-oxazolylmethoxy)-3-methoxyphenyl]ethyl]-2,4-oxazolidinedione
Reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH:10]2[O:14][C:13](=[O:15])[NH:12][C:11]2=[O:16])=[CH:4][C:3]=1[O:17][CH3:18].Cl[CH2:20][C:21]1[N:22]=[C:23]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[O:24][C:25]=1[CH3:26]>>[CH3:26][C:25]1[O:24][C:23]([C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)=[N:22][C:21]=1[CH2:20][O:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH:10]2[O:14][C:13](=[O:15])[NH:12][C:11]2=[O:16])=[CH:4][C:3]=1[O:17][CH3:18]Participants
3
Procedure
In substantially the same manner as in Working Example 9, 5-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-2,4-oxazolidinedione was reacted with 4-chloromethyl-5-methyl-2-phenyloxazole to obtain 5-[2-[4-(5-methyl-2-phenyl-4-oxazolylmethoxy)-3-methoxyphenyl]ethyl]-2,4-oxazolidinedione, which was recrystallized from ethyl acetate-chloroform to give colorless prisms, m.p.194-195° C.
Sources & evidence
- ORD record
- ord-2634f130ff874e25a80735932b5fb740
- Source dataset
- uspto-grants-1999_08
- Patent number
- US05932601
Reaction notes
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