反应详情

A mixture of 5-[3-[3-methoxy-4-[2-[(E)-styryl]-4-oxazolylmethoxy]phenyl]propyl]-2,4-oxazolidinedione (0.64 g), paradium-carbon (5%, 1.3 g) and tetrahydrofuran (THF) (35 ml) was subjected to catalytic hydrogenation under 1 atmospheric pressure at room temperature. The catalyst was filtered off, and the filtrate was concentrated under reduced pressure to yield 5-[3-[3-methoxy-4-[2-(2-phenylethyl)-4-oxazolylmethoxy]phenyl]propyl]-2,4-oxazolidinedione (0.43 g, 67%). The product was recrystallized from ethyl acetate-hexane to give colorless needles, m.p.122-123° C.

1. customwas subjected to catalytic hydrogenation under 1 atmospheric pressure at room temperature
2. filtrationThe catalyst was filtered off
3. concentrationthe filtrate was concentrated under reduced pressure