3-Fluoro-4-(5-methyl-2-phenyl-4-oxazolylmethoxy)nitrobenzene → 3-Fluoro-4-(5-methyl-2-phenyl-4-oxazolylmethoxy)aniline

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Reaction Steps

A mixture of 3-fluoro-4-(5-methyl-2-phenyl-4-oxazolylmethoxy)nitrobenzene (13.6 g), palladium-carbon (5%, 2.0 g) and tetrahydrofuran (THF) (200 ml) was subjected to catalytic hydrogenation under 1 atmospheric pressure at room temperature. The catalyst was filtered off, and the filtrate was concentrated under reduced pressure to yield 3-fluoro-4-(5-methyl-2-phenyl-4-oxazolylmethoxy)aniline as an oily product.

Provenance & Evidence