1,2-Difluoro-4-nitrobenzene → HCID 21224468, compound

HRID 1584370Notes

Reaction equation

HRID 1584370 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([N+:9]([O-:11])=[O:10])[CH:5]=[CH:6][C:7]=1F.[CH3:12][N:13]([CH2:20][CH2:21][OH:22])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=1>>[F:1][C:2]1[CH:3]=[C:4]([N+:9]([O-:11])=[O:10])[CH:5]=[CH:6][C:7]=1[O:22][CH2:21][CH2:20][N:13]([CH3:12])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=1

Participants

3

Reactant 2

HCID 1230531,2-Difluoro-4-nitrobenzeneHCID 7374202-(N-Methyl-N-(2-pyridyl)amino)ethanol

Product 1

HCID 21224468HCID 21224468, compound

Procedure

In substantially the same manner as in Reference Example 54, 3,4-difluoronitrobenzene was reacted with 2-[N-methyl-N-(2-pyridyl)amino]ethanol to yield 3-fluoro-4-[2-[N-methyl-N-(2-pyridyl)amino]ethoxy]nitrobenzene. The product was recrystallized from ethyl acetate-hexane to give yellow prisms, m.p.95-96° C.

Sources & evidence

ORD record
ord-aca5cc439b8b40128fc2fd4e37049b8a
Source dataset
uspto-grants-1999_08
Patent number
US05932601

Reaction notes

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