Diisobutylaluminumhydride → HCID 21224409, compound

HRID 1584371Notes

Reaction equation

HRID 1584371 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:11]=[CH:12][C:13]=1[O:14][CH2:15][CH2:16][N:17]([CH3:24])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=1)[CH:5]=[CH:6][C:7](OC)=[O:8].[H-].C([Al+]CC(C)C)C(C)C>>[F:1][C:2]1[CH:3]=[C:4](/[CH:5]=[CH:6]/[CH2:7][OH:8])[CH:11]=[CH:12][C:13]=1[O:14][CH2:15][CH2:16][N:17]([CH3:24])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=1

Participants

3

Reactant 2

HCID 21225700DiisobutylaluminumhydrideHCID 69831620HCID 69831620, compound

Product 1

HCID 21224409HCID 21224409, compound

Procedure

In substantially the same manner as in Reference Example 58, methyl 3-fluoro-4-[2-[N-methyl-N-(2-pyridyl)amino]ethoxy]cinnamate was subjected to reduction reaction with diisobutylaluminum hydride to yield (E)-3-(3-fluoro-4-[2-[N-methyl-N-(2-pyridyl)amino]ethoxy]phenyl]-2-propen-1-ol. The product was recrystallized from ethyl acetate-hexane to give colorless needles, m.p.80-81° C.

Sources & evidence

ORD record
ord-afc0805879a24a89a6df1931b40c0a07
Source dataset
uspto-grants-1999_08
Patent number
US05932601

Reaction notes

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