反应详情

A solution of sodium thiomethoxide (25 g) and 4-bromodiphenyl ether (25 g) in N,N-dimethylformamide (DMF) (150 ml) was refluxed overnight. The mixture was cooled and added to dilute aqueous sodium hydroxide. The water layer was washed with ether to remove by-products and acidified with hydrochloric acid. The product, 4-(phenoxy)thiophenol, was extracted with ether, and the ether layer dried and evaporated to give 4-(phenoxy)thiophenol (19-20 g) as a red oil. This material can be used without further purification.

1. temperatureThe mixture was cooled
2. washThe water layer was washed with ether
3. customto remove by-products
4. extractionThe product, 4-(phenoxy)thiophenol, was extracted with ether
5. dry with materialthe ether layer dried
6. customevaporated