反应详情

Combine 1-t-butoxycarbonyl-4-(1-(2-(2,2,2-trifluoroethoxy)ethyl)-1H-benzimidazol-2-yl)[1,4]diazepane (0.47 g, 1.1 mmol) and aqueous hydriodic acid (0.70 mL, 9,42 mmol) in methanol (10 mL). After 4 hours, evaporate to remove most of the methanol to give a residue. Combine the residue and diethyl ether (50 mL) and stir to give a solid. Collect the solid by filtration to give, after drying, the title compound: Rf =0.39 (silica gel, 10% methanol/dichloromethane/5% acetic acid).

1. customevaporate
2. customto remove most of the methanol
3. customto give a residue
4. customto give a solid
5. customCollect the solid
6. filtrationby filtration
7. customto give
8. customafter drying