反应详情

Combine 4-(1-(fur-2-ylmethyl)-1H-benzimidazol-2-yl)[1,4]diazepane hydrochloric acid salt (0.57 g, 1.53 mmol) and dichloromethane (150 mL). Extract with a saturated aqueous solution of sodium bicarbonate, dry over Na2SO4, filter, and evaporate in vacuo to give a residue. Combine the residue and methanol (50 mL). Cool in an ice bath. Add aqueous hydriodic acid (0.194 g, 57%, 1.52 mmol). After 30 minutes, evaporate to remove most of the methanol and triturate with diethyl ether (150 mL) to give a solid. Decant the solvent, add diethyl ether (150 mL) and collect the solid by filtration to give, after drying, the title compound.

1. extractionExtract with a saturated aqueous solution of sodium bicarbonate
2. dry with materialdry over Na2SO4
3. filtrationfilter
4. customevaporate in vacuo
5. customto give a residue
6. temperatureCool in an ice bath
7. customevaporate
8. customto remove most of the methanol
9. customtriturate with diethyl ether (150 mL)
10. customto give a solid
11. customDecant the solvent
12. additionadd diethyl ether (150 mL)
13. customcollect the solid
14. filtrationby filtration
15. customto give
16. customafter drying