Ethanol → 4-(1-(2-methoxyethyl)-1H-benzimidazol-2-yl)[1,4]diazepane hydriodic acid salt

HRID 1584502Notes

Reaction equation

HRID 1584502 reaction equation
C(OC([N:8]1[CH2:14][CH2:13][CH2:12][N:11]([C:15]2[N:19]([CH2:20][CH2:21][O:22][CH3:23])[C:18]3[CH:24]=[CH:25][CH:26]=[CH:27][C:17]=3[N:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[IH:28].C(O)C>C(OCC)C>[IH:28].[CH3:23][O:22][CH2:21][CH2:20][N:19]1[C:18]2[CH:24]=[CH:25][CH:26]=[CH:27][C:17]=2[N:16]=[C:15]1[N:11]1[CH2:12][CH2:13][CH2:14][NH:8][CH2:9][CH2:10]1

Participants

5

Reactant 3

HCID 702EthanolHCID 24841Hydrogen iodideHCID 18464882HCID 18464882, compound

Product 1

HCID 867543614-(1-(2-methoxyethyl)-1H-benzimidazol-2-yl)[1,4]diazepane hydriodic acid salt

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Combine 1-(t-butoxycarbonyl)-4-(1-(2-methoxyethyl)-1H-benzimidazol-2-yl) [1,4]diazepane (1.69 g, 5.23 mmol), aqueous hydriodic acid (10 mL, 57%), and ethanol (20 mL). Heat to reflux. After 1 hour, cool to ambient temperature and pour the reaction mixture into diethyl ether (350 mL) and stir to give a solid. After 1 hour, collect the solid and dry in vacuo to give the title compound.

Workup

  1. temperatureHeat to reflux
  2. customto give a solid
  3. waitAfter 1 hour
  4. customcollect the solid
  5. customdry in vacuo

Sources & evidence

ORD record
ord-08698a790d7248939fadc6862545afe9
Source dataset
uspto-grants-1999_08
Patent number
US05932571

Reaction notes

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