Hydrochloric Acid → HCID 21022648, compound

HRID 1584551Notes

Reaction equation

HRID 1584551 reaction equation
[OH:1][N:2]1[C:7]([CH3:9])([CH3:8])[CH2:6][CH:5]([O:10][CH2:11][C:12]([O:14]CC)=[O:13])[CH2:4][C:3]1([CH3:18])[CH3:17].[OH-].[Na+].Cl>O.CO>[OH:1][N:2]1[C:7]([CH3:9])([CH3:8])[CH2:6][CH:5]([O:10][CH2:11][C:12]([OH:14])=[O:13])[CH2:4][C:3]1([CH3:18])[CH3:17]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 69035975HCID 69035975, compound

Product 1

HCID 21022648HCID 21022648, compound

Reagents, catalysts & solvents 1

HCID 22242641Methanol--water (1/1)Solvent

Procedure

1.0 g (39 mmol) of the compound of Example 6 is added to a solution of 0.2 g sodium hydroxide in 20 mL of 1:1 water/methanol. The mixture is stirred for one hour, carefully acidified with 1% aqueous hydrogen chloride and then extracted with ethyl acetate. The organic extract is dried over anhydrous magnesium sulfate and then contentrated to afford the title compound as an orange solid.

Workup

  1. extractionextracted with ethyl acetate
  2. extractionThe organic extract
  3. dry with materialis dried over anhydrous magnesium sulfate

Sources & evidence

ORD record
ord-b0f4c6e95efb4e7eb18af4cc6299815a
Source dataset
uspto-grants-1999_08
Patent number
US05932735

Reaction notes

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