Cyclopropanecarbonyl chloride → HCID 15428621, compound

HRID 1584594Notes

Reaction equation

O.Cl.Cl.[CH3:4][N:5]([CH3:20])[CH:6]1[CH2:19][CH2:18][C:9]2[O:10][C:11]3[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][C:12]=3[C:8]=2[CH2:7]1.CN(C)C1CCC2[O:27][C:28]3[CH:33]=[CH:32][C:31](N)=CC=3C=2C1.Cl.Cl.C1(C(Cl)=O)CC1>>[CH3:4][N:5]([CH3:20])[CH:6]1[CH2:19][CH2:18][C:9]2[O:10][C:11]3[CH:16]=[CH:15][C:14]([NH:17][C:28]([CH:33]4[CH2:31][CH2:32]4)=[O:27])=[CH:13][C:12]=3[C:8]=2[CH2:7]1

Participants

Reactant 2

HCID 77637Cyclopropanecarbonyl chloride

HCID 69947452HCID 69947452, compound

Product 1

HCID 15428621HCID 15428621, compound

Procedure

Beginning with 9.0 mg (0.029 mMol) of N,N-dimethyl-8-amino-1,2,3,4-tetrahydro-2-dibenzofuranamine dihydrochloride hemihydrate and 4.3 mg (0.036 mMol) of cyclopropanecarbonyl chloride, the title compound was recovered by the procedure described in Example 2.

Workup

customthe title compound was recovered by the procedure

Sources & evidence

ORD record: ord-b04fd8b9c5154fe7a4c05db4b05e942c
Source dataset: uspto-grants-1999_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05932739

Reaction notes

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