Ethanol → HCID 21219747, compound

HRID 1584710Notes

Reaction equation

HRID 1584710 reaction equation
C(O)C.[OH-].[K+].C([O:9][C:10]1[CH:15]=[C:14]([O:16][CH2:17][CH2:18][CH2:19][CH3:20])[CH:13]=[CH:12][C:11]=1[O:21][CH2:22][CH2:23][CH2:24][CH3:25])(=O)C>O>[CH2:22]([O:21][C:11]1[CH:12]=[CH:13][C:14]([O:16][CH2:17][CH2:18][CH2:19][CH3:20])=[CH:15][C:10]=1[OH:9])[CH2:23][CH2:24][CH3:25]

Participants

5

Reactant 3

HCID 702EthanolHCID 14797Potassium HydroxideHCID 21219737HCID 21219737, compound

Product 1

HCID 21219747HCID 21219747, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

23 [ml] of ethanol, 51.1 [g] of potassium hydroxide and 53.0 [g] of 2-acetoxy-1,4-di-n-butoxybenzene were added to 255 [ml] of water, and the mixture was reacted at 80° C. while stirring for 1 hour. After cooling the reaction liquor, it was neutralized and extracted twice with 200 [ml] of ethyl acetate. The extraction solution (i.e. the ethyl acetate solution) was washed with water, and concentrated by evaporating off the ethyl acetate as solvent under reduced pressure. Concentration of the extraction solution was continued until there was effectively no further evaporation of ethyl acetate (i.e., effectively no further ethyl acetate remained in the extraction solution). The separated crystals were filtered using filter paper, washed with a small amount of ethyl acetate, and dried to obtain 35.1 [g] of 2,5-di-n-butoxyphenol.

Workup

  1. customthe mixture was reacted at 80° C.
  2. temperatureAfter cooling the reaction liquor, it
  3. extractionextracted twice with 200 [ml] of ethyl acetate
  4. washThe extraction solution (i.e. the ethyl acetate solution) was washed with water
  5. concentrationconcentrated
  6. customby evaporating off the ethyl acetate as solvent under reduced pressure
  7. customno further evaporation of ethyl acetate (i.e.
  8. filtrationThe separated crystals were filtered
  9. filtrationusing filter paper
  10. washwashed with a small amount of ethyl acetate
  11. customdried

Sources & evidence

ORD record
ord-7f7712a18b28485ca429a55cc32053a2
Source dataset
uspto-grants-1999_08
Patent number
US05935756

Reaction notes

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