Propionyl chloride → HCID 53770034, compound

HRID 1584713Notes

Reaction equation

HRID 1584713 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[OH:9].[C:10](Cl)(=[O:13])[CH2:11][CH3:12]>N1C=CC=CC=1.C1(C)C=CC=CC=1.C(OCC)(=O)C>[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[O:9][C:10](=[O:13])[CH2:11][CH3:12]

Participants

6

Reactant 2

HCID 62324Propionyl chlorideHCID 949522,5-Difluorophenol

Product 1

HCID 53770034HCID 53770034, compound

Reagents, catalysts & solvents 3

HCID 1049PyridineSolventHCID 1140TolueneSolventHCID 8857Ethyl AcetateSolvent

Procedure

At 0° C.-5° C., a solution of 100 g of 2,5-difluorophenol in 66.5 g of pyridine is added dropwise in the course of 2 hours to a solution of 71.2 g of propionic acid chloride in 800 ml of toluene and stirring is then carried out at room temperature for a further hour. The reaction mixture is then diluted with ethyl acetate, washed twice with water and once with saturated sodium chloride solution and the organic phase is separated off, dried with sodium sulfate and concentrated by evaporation in vacuo. The crude product is processed further without further purification.

Workup

  1. waitis then carried out at room temperature for a further hour
  2. washwashed twice with water and once with saturated sodium chloride solution
  3. customthe organic phase is separated off
  4. dry with materialdried with sodium sulfate
  5. concentrationconcentrated by evaporation in vacuo
  6. customThe crude product is processed further without further purification

Sources & evidence

ORD record
ord-6eef0feee6ec4a66844e1f7b634daedd
Source dataset
uspto-grants-1999_08
Patent number
US05935908

Reaction notes

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