HCID 53648913, compound → HCID 18545098, compound

HRID 1584762Notes

Reaction equation

HRID 1584762 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][N:11]([C:14](=[O:28])[CH:15]([NH:20]C(=O)OC(C)(C)C)[CH2:16][CH:17]([CH3:19])[CH3:18])[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.FC1C=CC(N2CCN(C(=O)C(NC(=O)OC(C)(C)C)CC3C=CC=CC=3)CC2)=CC=1>>[ClH:1].[NH2:20][CH:15]([CH2:16][CH:17]([CH3:19])[CH3:18])[C:14]([N:11]1[CH2:10][CH2:9][N:8]([C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=2)[CH2:13][CH2:12]1)=[O:28]

Participants

3

Reactant 2

HCID 53648913HCID 53648913, compoundHCID 538047351,1-Dimethylethyl 2-(4-(4-fluorophenyl)-1-piperazinyl)-2-oxo-1-(phenylmethyl)ethylcarbamate

Product 1

HCID 18545098HCID 18545098, compoundYield 65.3%

Procedure

Using 1,1-dimethylethyl 2-(4-(4-chlorophenyl)-1-piperazinyl)-2-oxo-1-(2-methylpropyl)ethylcarbamate in lieu of 1,1-dimethylethyl 2-(4-(4-fluorophenyl)-1-piperazinyl)-2-oxo-1-(phenylmethyl)ethylcarbamate, the procedure of Reference Example 13 was otherwise repeated to provide 1-(2-amino-4-methyl-1-oxopentyl)-4-(4-chlorophenyl)piperazine hydrochloride (1.50 g, 65.3%) as white crystals.

Sources & evidence

ORD record
ord-51e1763d67f14555a1dbaeec27256ad9
Source dataset
uspto-grants-1999_08
Patent number
US05935959

Reaction notes

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