Potassium Carbonate → HCID 21220888, compound

HRID 1584779Notes

Reaction equation

HRID 1584779 reaction equation
[O:1]1[CH2:6][CH2:5][CH2:4][O:3][CH:2]1[C:7]1[C:15]2[O:14][CH:13]=[CH:12][C:11]=2[CH:10]=[C:9]([C:16]#[C:17][Si](C)(C)C)[CH:8]=1.C(=O)([O-])[O-].[K+].[K+]>CO>[O:1]1[CH2:6][CH2:5][CH2:4][O:3][CH:2]1[C:7]1[C:15]2[O:14][CH:13]=[CH:12][C:11]=2[CH:10]=[C:9]([C:16]#[CH:17])[CH:8]=1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 21220961HCID 21220961, compound

Product 1

HCID 21220888HCID 21220888, compoundYield 98.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 7-[1,3]dioxan-2-yl-5-trimethylsilylethynyl-benzofuran (330 mg), and potassium carbonate (40 mg) in anhydrous methanol (10 ml) was stirred at room temperature for 1 h. The solvent was removed in vacuo, the residue treated with water (50 ml), and extracted with ether (3×75 ml). The combined organic extracts were washed with sodium hydroxide (50 ml; 2M), dried, and evaporated in vacuo to give the title compound as a brown oil (247 mg).

Workup

  1. customThe solvent was removed in vacuo
  2. additionthe residue treated with water (50 ml)
  3. extractionextracted with ether (3×75 ml)
  4. washThe combined organic extracts were washed with sodium hydroxide (50 ml; 2M)
  5. customdried
  6. customevaporated in vacuo

Sources & evidence

ORD record
ord-52270370043c44cf9f9da4995eeafb47
Source dataset
uspto-grants-1999_08
Patent number
US05935972

Reaction notes

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