反应详情

α,α-Bis-(4-fluorophenyl)-1-(triphenylmethyl)-4-piperidinemethanol (67 g; 0.123 mol) was dissolved in hydrochloric acid (1 l; 2 mol/l) and the solution was heated under reflux for 2 h. The solution was cooled, the precipitated solid was collected by filtration and suspended in anhydrous diethyl ether. The mixture was stirred for 1 h, filtered and the solid was crystallised from methanol/ether to give the product (28.3 g) as white crystals; m.p. 83° C.

1. temperaturethe solution was heated
2. temperatureunder reflux for 2 h
3. temperatureThe solution was cooled
4. filtrationthe precipitated solid was collected by filtration
5. filtrationfiltered
6. customthe solid was crystallised from methanol/ether