Hydrochloric Acid → HCID 21220450, compound

HRID 1584808Notes

Reaction equation

HRID 1584808 reaction equation
[NH2:1][C:2]1[C:12]([F:13])=[CH:11][C:5]([C:6]([O:8]CC)=[O:7])=[C:4]([F:14])[C:3]=1[CH3:15].[OH-].[Na+].Cl>C(O)C>[NH2:1][C:2]1[C:12]([F:13])=[CH:11][C:5]([C:6]([OH:8])=[O:7])=[C:4]([F:14])[C:3]=1[CH3:15]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 21220385HCID 21220385, compound

Product 1

HCID 21220450HCID 21220450, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In 50 ml of ethanol was dissolved 8.91 g of ethyl 4-amino-2,5-difluoro-3-methylbenzoate, and 50 ml of 2N aqueous sodium hydroxide solution was added to the solution, after which the resulting mixture was stirred at room temperature for three hours. To the reaction mixture was added 50 ml of 2N hydrochloric acid, and the resulting crystals were collected by filtration, to obtain 5.45 g of colorless, crystalline 4-amino-2,5-difluoro-3-methylbenzoic acid.

Workup

  1. additionwas added to the solution
  2. filtrationthe resulting crystals were collected by filtration

Sources & evidence

ORD record
ord-559331e23fd84410b91a1e981358c85a
Source dataset
uspto-grants-1999_08
Patent number
US05935952

Reaction notes

Loading…