Potassium Cation → 1-(benzo[d][1,3]dioxol-5-yl)-N-(4'-(hydroxymethyl)-6-methylbiphenyl-3-yl)cyclopropanecarboxamide

HRID 158485Notes

Reaction equation

HRID 158485 reaction equation
[CH3:41][N:42]([CH3:43])[CH:44]=[O:45].[K+:35].[K+:36].[O-:37][C:38]([O-:39])=[O:40].[O:1]1[CH2:2][O:3][c:4]2[c:5]1[cH:6][cH:7][c:8]([C:10]1([C:13](=[O:14])[NH:15][c:16]3[cH:17][c:18]([Br:23])[c:19]([CH3:22])[cH:20][cH:21]3)[CH2:11][CH2:12]1)[cH:9]2.[OH:24][CH2:25][c:26]1[cH:27][cH:28][c:29]([B:32]([OH:33])[OH:34])[cH:30][cH:31]1>>[O:1]1[CH2:2][O:3][c:4]2[c:5]1[cH:6][cH:7][c:8]([C:10]1([C:13](=[O:14])[NH:15][c:16]3[cH:17][c:18](-[c:29]4[cH:28][cH:27][c:26]([CH2:25][OH:24])[cH:31][cH:30]4)[c:19]([CH3:22])[cH:20][cH:21]3)[CH2:11][CH2:12]1)[cH:9]2

Participants

6

Reactant 5

HCID 813Potassium Cation2×HCID 6228DimethylformamideHCID 19660Carbonate IonHCID 27347064-(Hydroxymethyl)benzeneboronic acidHCID 592060871-(Benzo[d][1,3]dioxol-5-yl)-N-(3-bromo-4-methylphenyl)cyclopropanecarboxamide

Product 1

HCID 592059701-(benzo[d][1,3]dioxol-5-yl)-N-(4'-(hydroxymethyl)-6-methylbiphenyl-3-yl)cyclopropanecarboxamide

Sources & evidence

ORD record
ord-77173ef5748c495d9b40dd7f2e4a1c90
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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