Hydrazine → HCID 21220645, compound

HRID 1584850Notes

Reaction equation

HRID 1584850 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[C:5]([C:13]([O:15][CH2:16][CH3:17])=[O:14])=[CH:4][N:3]=1.[NH2:18][NH2:19]>C1COCC1>[NH:18]([C:2]1[N:7]=[C:6]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[C:5]([C:13]([O:15][CH2:16][CH3:17])=[O:14])=[CH:4][N:3]=1)[NH2:19]

Participants

4

Reactant 2

HCID 9321HydrazineHCID 21220647Diethyl 2-chloropyrimidine-4,5-dicarboxylate

Product 1

HCID 21220645HCID 21220645, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The title compound was prepared as described in Example 18, but employing a solution of diethyl 2-chloropyrimidine-4,5-dicarboxylate (0.21 g, 0.83 mmol) and hydrazine (0.13 g, 4.2 mmol) in THF (10 mL) resulting in 96% yield (0.20 g); 1H NMR (CDCl3) δ 8.93 (bs, 1H), 8.34 (bs, 1H), 4.40 (m, 4H), 4.18 (bs, 2H), 1.35 (m, 6H).

Workup

  1. customresulting in 96% yield (0.20 g)

Sources & evidence

ORD record
ord-89299247ebac45c094396b9c685576fe
Source dataset
uspto-grants-1999_08
Patent number
US05935966

Reaction notes

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