Hydrazine → HCID 21220632, compound

HRID 1584853Notes

Reaction equation

HRID 1584853 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]([F:14])([F:13])[C:9]([F:12])([F:11])[F:10])[C:5]([C:15]([O:17][CH3:18])=[O:16])=[CH:4][N:3]=1.ClC1N=C(C(F)(F)C(F)(F)F)C(C(Cl)=O)=CN=1.[NH2:36][NH2:37]>CO>[NH:36]([C:2]1[N:7]=[C:6]([C:8]([F:14])([F:13])[C:9]([F:12])([F:11])[F:10])[C:5]([C:15]([O:17][CH3:18])=[O:16])=[CH:4][N:3]=1)[NH2:37]

Participants

5

Reactant 3

HCID 9321HydrazineHCID 10756259HCID 10756259, compoundHCID 21220608HCID 21220608, compound

Product 1

HCID 21220632HCID 21220632, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The title compound was prepared according to the procedure of Example 47 but employing a solution of methyl 2-chloro-4-pentafluoroethylpyrimidine-5-carboxylate (0.55 g, 1.9 mmol; itself prepared by a reaction of methanol with 2-chloro-4-pentafluoroethylpyrimidine-5-carbonyl chloride (see Example 17)) and hydrazine (0.3 g, 9.4 mmol), resulting in a yield of 99% (0.54 g); 1HNMR (CDCl3) δ 8.87 (s, 1H), 7.09 (s, 1H), 3.92 (s, 3H), 1.7 (s, 2H).

Workup

  1. customresulting in a yield of 99% (0.54 g)

Sources & evidence

ORD record
ord-a5ecb412c0464f22983825764b86bbbd
Source dataset
uspto-grants-1999_08
Patent number
US05935966

Reaction notes

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