Trifluoroacetic acid → HCID 21221049, compound

HRID 1584872Notes

Reaction equation

HRID 1584872 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[NH2:8][C:9]1[C:14]([C:15]([NH:17][CH2:18][CH:19]2[CH2:24][CH2:23][N:22](C(OC(C)(C)C)=O)[CH2:21][CH2:20]2)=[O:16])=[CH:13][CH:12]=[CH:11][N:10]=1>ClCCl>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[NH2:8][C:9]1[C:14]([C:15]([NH:17][CH2:18][CH:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)=[O:16])=[CH:13][CH:12]=[CH:11][N:10]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 186899742-amino-N-[(1-tert-butoxycarbonyl-4-piperidyl)methyl]pyridine-3-carboxamide

Product 1

HCID 21221049HCID 21221049, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Trifluoroacetic acid (9 ml) was added to a solution of 2-amino-N-[(1-tert-butoxycarbonyl-4-piperidyl)methyl]pyridine-3-carboxamide (2.2 g; prepared in a similar manner to that described above) in dichloromethane (50 ml) and the mixture stirred at ambient temperature for 1 hour. The solvent was removed in vacuo to give crude 2-amino-N-(4-piperidylmethyl)pyridine-3-carboxamide trifluoroacetate.

Workup

  1. customprepared in a similar manner to that
  2. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-7c253e569efd40f491d58728081f4844
Source dataset
uspto-grants-1999_08
Patent number
US05935973

Reaction notes

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