反应详情

2-Pyridone (4.76 g, 50 mmol) and ethyl bromoacetate (10.02 g, 60 mmol) were dissolved in acetone (100 ml). Potassium carbonate (8.28 g, 60 mmol) was added to the solution and the mixture was refluxed for two hours with stirring. After being cooled, insoluble substances were removed by filtration and the filtrate was evaporated to dryness. The residue was purified by silica gel column chromatography, to thereby obtain N-ethoxycarbonylmethyl-2-pyridone (7.60 g, yield 84%).

1. temperaturethe mixture was refluxed for two hours
2. temperatureAfter being cooled
3. custominsoluble substances were removed by filtration
4. customthe filtrate was evaporated to dryness
5. customThe residue was purified by silica gel column chromatography