Water → Pyridinium trifluoromethanesulfonate

HRID 1585231Notes

Reaction equation

HRID 1585231 reaction equation
COC1C=CC=CC=1CC(C1[CH:20]2[C:15](CO)(CC3C=CC=CC=3[CH:19]2[C:21]2C=CC=CC=2)[CH2:14][NH:13]1)=O.[F:33][C:34]([F:47])([F:46])[S:35]([O:38]S(C(F)(F)F)(=O)=O)(=[O:37])=[O:36].O>N1C=CC=CC=1>[F:33][C:34]([F:47])([F:46])[S:35]([O-:38])(=[O:37])=[O:36].[NH+:13]1[CH:14]=[CH:15][CH:20]=[CH:19][CH:21]=1

Participants

5

Reactant 3

HCID 962WaterHCID 67749Trifluoromethanesulfonic anhydrideHCID 86754403HCID 86754403, compound

Product 1

HCID 2734866Pyridinium trifluoromethanesulfonate

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

500 mg (1.1 mmol) of (3aRS, 4SR, 9SR, 9aRS)-4,9-ethano-2-(2-methoxyphenyl)acetyl-9-phenyl-2,3,3a,4,9,9a-hexahydro-1H-benzo[f]isoindole-3a-methanol are dissolved, at a temperature in the region of 20° C. under a nitrogen atmosphere, in 10 cm3 of pyridine which has been dried over potassium hydroxide and then 336 mg (1.2 mmol) of trifluoromethanesulphonic anhydride are added. After stirring for 3 hours at a temperature in the region of 20° C., 25 cm3 of water are added and extraction is carried out with 3 times 25 cm3 dichloromethane. The combined organic phases are washed with 0.1N hydrochloric acid and then with water, dried over magnesium sulphate and concentrated to dryness under reduced pressure. The residue is purified by recrystallizing from a methanol/isopropyl ether (60/40 by volume) mixture. 310 mg (42%) of N-[(3aRS, 4SR, 9SR, 9aRS)-4,9-ethano-2-(2-methoxyphenyl)acetyl-9-phenyl-2,3,3a,4,9,9a-hexahydro-1H-benzo[f]isoindolyl-3a-methyl]pyridinium trifluoromethanesulphonate are thus obtained in the form of pale-yellow crystals, the characteristics of which are as follows: melting point=244° C., 1H N.M.R. spectrum (250 MHz, d6-(CD3)2SO, at a temperature of 393 K, δ in ppm): 1.37, 1.67, 1.98 and 2.12 (4 mts, each 1H, CH2CH2), 2.80 (mt, 1H, H at 9a), 3.20 (mt, 1H, H at 4), 3.38 (limit AB, 2H, CH2 at 1), 3.52 (broad s, 2H, COCH2Ar), 3.56 at 4.02 (2 d, J=12.5 Hz, each 1H, CH2 at 3), 3.68 (unresolved peak, 3H, OCH3), 4.38 and 4.50 (2 d, J=12.5 Hz, each 1H, CH2N+), 6.51 (broad d, J=7.5 Hz, 1H, H at 8), 6.88 (broad t, J=7.5 Hz, 1H, aromatic H para to the OCH3), 6.95 (broad d, J=7.5 Hz, 1H, aromatic H ortho to OCH3), 7.15 (dt, J=7.5 and 2 Hz, 1H, H at 7), from 7.20 to 7.45 (mt, 4H, H at 5, H at 6 and aromatic H meta to the OCH3), from 7.35 to 7.60 (mt, 5H, aromatic H of the phenyl at 9), 8.15 (broad t, J=7 Hz, 2H, H at 3 and H at 5 of the pyridyl), 8.65 (broad t, J=7 Hz, 1H, H at 4 of the pyridyl), 8.91 (broad t, J=7 Hz, 2H, H at 2 and H at 6 of the pyridyl).

Workup

  1. dry with materialhas been dried over potassium hydroxide
  2. additionare added
  3. extractionextraction
  4. washThe combined organic phases are washed with 0.1N hydrochloric acid
  5. dry with materialwith water, dried over magnesium sulphate
  6. concentrationconcentrated to dryness under reduced pressure
  7. customThe residue is purified
  8. customby recrystallizing from a methanol/isopropyl ether (60/40 by volume) mixture

Sources & evidence

ORD record
ord-931bfc26735c46f1940496305dc722fe
Source dataset
uspto-grants-1999_08
Patent number
US05936097

Reaction notes

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