Potassium Hydroxide → HCID 21218507, compound

HRID 1585471Notes

Reaction equation

HRID 1585471 reaction equation
[F:1][C:2]1[CH:18]=[C:17]([F:19])[CH:16]=[CH:15][C:3]=1[O:4][C:5]1[C:10]([C:11]([O:13]C)=[O:12])=[N:9][CH:8]=[CH:7][N:6]=1.[OH-].[K+]>CO.O>[F:1][C:2]1[CH:18]=[C:17]([F:19])[CH:16]=[CH:15][C:3]=1[O:4][C:5]1[C:10]([C:11]([OH:13])=[O:12])=[N:9][CH:8]=[CH:7][N:6]=1

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 21218508HCID 21218508, compound

Product 1

HCID 21218507HCID 21218507, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

A solution of 5.3 g (20 mmol) of methyl 2-(2,4-difluorophenoxy)-3-pyrazinecarboxylate in 50 ml of methanol is treated with 5.6 g (0.1 mol) of potassium hydroxide at room temperature for 2 hours. The reaction mixture is freed from the solvent under reduced pressure and the residue is taken up in distilled water. On acidification to pH 2-3, the 2-(2,4-difluorophenoxy)-3-pyrazinecarboxylic acid is precipitated from the solution.

Workup

  1. customOn acidification to pH 2-3, the 2-(2,4-difluorophenoxy)-3-pyrazinecarboxylic acid is precipitated from the solution

Sources & evidence

ORD record
ord-fac52ac457904b4f99f0a6eb9920065e
Source dataset
uspto-grants-1999_08
Patent number
US05939359

Reaction notes

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