Potassium Hydroxide → HCID 21218507, compound

Participants

Reaction Steps

A solution of 5.3 g (20 mmol) of methyl 2-(2,4-difluorophenoxy)-3-pyrazinecarboxylate in 50 ml of methanol is treated with 5.6 g (0.1 mol) of potassium hydroxide at room temperature for 2 hours. The reaction mixture is freed from the solvent under reduced pressure and the residue is taken up in distilled water. On acidification to pH 2-3, the 2-(2,4-difluorophenoxy)-3-pyrazinecarboxylic acid is precipitated from the solution.

Provenance & Evidence