反应详情

3.1 g (0.01 mol) (3RS)-1-benzyl-3-(N-tert-butyloxycarbonylaminoethyl) pyrrolidine was hydrogenated at 0.28 MPa over 0.6 g of Pearlman's catalyst (Pd(OH)2) in 40 ml ethanol (95%) over night. After filtration of the catalyst through cellite and evaporation of the solvent 1H-NMR showed that the reaction was not completed. Therefore 0.6 g of Pearlman's catalyst was added in 40 ml ethanol (95%) once more and the mixture was treated under H2 -atmosphere at 0.28 MPa over night. Filtration through cellite and evaporation of the solvent gave the product in a quantitative yield (2.18 g).

1. filtrationAfter filtration of the catalyst
2. customthrough cellite and evaporation of the solvent
3. additionTherefore 0.6 g of Pearlman's catalyst was added in 40 ml ethanol (95%) once more
4. additionthe mixture was treated under H2 -atmosphere at 0.28 MPa over night
5. filtrationFiltration
6. customthrough cellite and evaporation of the solvent
7. customgave the product in a quantitative yield (2.18 g)