反应详情

A solution of 37 g. (0.118 mole) of 3-carboxy-1,4-dimethyl-5-(p-toluoyl)-pyrrole-2 -acetic acid in 370 ml. of ethanol containing 1.8 g. of dry hydrogen chloride is heated under reflux for 45 minutes. The solution is cooled, and the solid which precipitated, ethyl 3 -carboxy-1,4-dimethyl-5-(o-toluoyl)-pyrrole-2-acetate, is collected, m.p. 200-202° C.

1. temperatureunder reflux for 45 minutes
2. temperatureThe solution is cooled
3. customthe solid which precipitated
4. customethyl 3 -carboxy-1,4-dimethyl-5-(o-toluoyl)-pyrrole-2-acetate, is collected