1H-1,2,4-Triazole → HCID 18786630, compound

HRID 1585665Notes

Reaction equation

HRID 1585665 reaction equation
[CH2:1]([O:8][CH2:9][CH2:10][S:11][C:12]([F:25])([F:24])[C:13]1([C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][C:17]=2[F:23])[O:15][CH2:14]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:26]1[CH:30]=[N:29][CH:28]=[N:27]1.C(=O)([O-])[O-].[K+].[K+]>CS(C)=O>[CH2:1]([O:8][CH2:9][CH2:10][S:11][C:12]([F:25])([F:24])[C:13]([C:16]1[CH:21]=[CH:20][C:19]([F:22])=[CH:18][C:17]=1[F:23])([OH:15])[CH2:14][N:26]1[CH:30]=[N:29][CH:28]=[N:27]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 92571H-1,2,4-TriazoleHCID 11430Potassium CarbonateHCID 154343851-(2-Benzyloxyethyl)thio-2-(2,4-difluorophenyl)-1,1-difluoro-2,3-epoxypropane

Product 1

HCID 18786630HCID 18786630, compoundYield 17.6%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

Using 1-(2-benzyloxyethyl)thio-2-(2,4-difluorophenyl)-1,1-difluoro-2,3-epoxypropane (3.0 g, 0.008 mol), DMSO (30 ml), 1,2,4-triazole (1.4 g, 0.02 mol) and potassium carbonate (2.8 g, 0.02 mol), 1-(2-benzyloxyethyl)thio-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-1,2,4-triazol-1-yl)propan-2-ol (0.62 g, yield: 17.4%) was obtained as a colorless oil by similar procedures to Example 14.

Sources & evidence

ORD record
ord-29585741299840c797d516b214b82546
Source dataset
uspto-grants-1999_08
Patent number
US05939448

Reaction notes

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