反应详情

温度

5 °C

A mixture of the title product of Step (C) (210 mg; 0.35 mmol), 6N HCl (5 ml) and EtOH (5 ml) was refluxed for 1.5 hours. A solid began precipitating during the reaction. After slowly cooling to 5° C., the suspension was filtered and the solid was washed with water. Drying afforded 154 mg (87%) of the title product of this Example as a cream colored solid. mp 207-209° C. (dec.; darkened at 196° C.); Rf=0.50, EtOAc (UV detection).

1. temperaturewas refluxed for 1.5 hours
2. customA solid began precipitating during the reaction
3. filtrationthe suspension was filtered
4. washthe solid was washed with water
5. customDrying