Hydrochloric Acid → HCID 86754415, compound

HRID 1585810Notes

Reaction equation

HRID 1585810 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([C@@:9]2([CH3:22])[C:13](=[O:14])[N:12]([CH2:15][C:16]([O:18][CH3:19])=[O:17])[C:11](=[O:20])[N:10]2[CH3:21])=[CH:5][CH:4]=1)#[N:2].[ClH:23].[CH2:24]([OH:26])[CH3:25]>>[ClH:23].[CH2:24]([O:26][C:1](=[NH:2])[C:3]1[CH:4]=[CH:5][C:6]([C@@:9]2([CH3:22])[C:13](=[O:14])[N:12]([CH2:15][C:16]([O:18][CH3:19])=[O:17])[C:11](=[O:20])[N:10]2[CH3:21])=[CH:7][CH:8]=1)[CH3:25]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 54456549HCID 54456549, compound

Product 1

HCID 86754415HCID 86754415, compound

Procedure

A solution of 2.56 g of methyl (S)-(4-(4-cyanophenyl)-3,4-dimethyl-2,5-dioxoimidazolidin-1-yl)acetate (8.5 mmol) in 40 ml of absolute ethanol was cooled to 0° C. Dry hydrogen chloride gas was passed into the solution, the temperature always being kept below 10° C., until the nitrile band was no longer present in the IR spectrum. The ethanolic solution was concentrated to 20 ml and treated with 200 ml of diethyl ether. The suspension was concentrated and dried in a high vacuum.

Workup

  1. concentrationThe ethanolic solution was concentrated to 20 ml
  2. additiontreated with 200 ml of diethyl ether
  3. concentrationThe suspension was concentrated
  4. customdried in a high vacuum

Sources & evidence

ORD record
ord-37da61719be746149316740a0da6bc5f
Source dataset
uspto-grants-1999_08
Patent number
US05939556

Reaction notes

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