HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → 2-Hydroxy-4-imidazol-1-ylmethyl-benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | 4-(Bromomethyl)-2-hydroxybenzonitrile | HCID 21696993 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-Hydroxy-4-imidazol-1-ylmethyl-benzonitrile | HCID 21697028 | — |
Reaction Steps
4-Bromomethyl-2-hydroxybenzonitrile (0.222 g, 1.045 mmol) and imidazole (0.356 g, 5.23 mmol) were stirred in DMF (10 mL) at ambient temperature for 18 hr. The reaction mixture was concentrated in vacuo to remove the DMF, and the residue was chromatographed (SiO2, 2-5% CH3OH in CH2Cl2) to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05939439 |
| Source dataset | uspto-grants-1999_08 |
| ORD ID | ord-0a5f31d60b2a48a69cf2052e1752506b |
| Source note | uspto-grants-1999_08 |