反应详情

4-Bromomethyl-2-hydroxybenzonitrile (0.222 g, 1.045 mmol) and imidazole (0.356 g, 5.23 mmol) were stirred in DMF (10 mL) at ambient temperature for 18 hr. The reaction mixture was concentrated in vacuo to remove the DMF, and the residue was chromatographed (SiO2, 2-5% CH3OH in CH2Cl2) to give the title compound.

1. concentrationThe reaction mixture was concentrated in vacuo
2. customto remove the DMF
3. customthe residue was chromatographed (SiO2, 2-5% CH3OH in CH2Cl2)