Methanol → 1-Chloro-4-methoxy-phthalazine

HRID 1585983Notes

Reaction equation

HRID 1585983 reaction equation
[Na].[Cl:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6](Cl)=[N:5][N:4]=1.[CH3:14][OH:15]>>[CH3:14][O:15][C:6]1[C:7]2[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]([Cl:2])=[N:4][N:5]=1

Participants

4

Reactant 3

HCID 887MethanolHCID 784901,4-DichlorophthalazineHCID 5360545Sodium

Product 1

HCID 64011971-Chloro-4-methoxy-phthalazine

Procedure

0.23 g(0.01 mol) of metallic sodium was dissolved in 50 ml of absolute methanol and then 1.99 g(0.01 mol) of 1,4-dichlorophthalazine was added thereto and completely dissolved. The reaction solution was stirred for one hour at room temperature and then treated according to the same manner as Preparation 5 to obtain the title compound as an amorphous white crystal.

Workup

  1. dissolutioncompletely dissolved
  2. additiontreated
  3. customaccording to the same manner as Preparation 5

Sources & evidence

ORD record
ord-a4516c57891d4b7f858edff39e305274
Source dataset
uspto-grants-1999_08
Patent number
US05942511

Reaction notes

Loading…