Ethanol → 1-Chloro-4-ethoxyphthalazine

HRID 1585985Notes

Reaction equation

HRID 1585985 reaction equation
[Na].Cl[C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([Cl:13])=[N:5][N:4]=1.[CH2:14]([OH:16])[CH3:15]>>[CH2:14]([O:16][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([Cl:13])=[N:5][N:4]=1)[CH3:15]

Participants

4

Reactant 3

HCID 702EthanolHCID 784901,4-DichlorophthalazineHCID 5360545Sodium

Product 1

HCID 212176601-Chloro-4-ethoxyphthalazine

Conditions

Temperature
50 °C

Procedure

0.69 g(0.03 mol) of metallic sodium was dissolved in 100 ml of absolute ethanol and then 5.97 g(0.03 mol) of 1,4-dichlorophthalazine was added thereto and completely dissolved. The reaction solution was stirred for one hour at 50±10° C. and then treated according to the same manner as Preparation 5 to obtain the title compound as a white needle crystal.

Workup

  1. dissolutioncompletely dissolved
  2. additiontreated
  3. customaccording to the same manner as Preparation 5

Sources & evidence

ORD record
ord-7d5ffe21acba44a79dcdbc3ea1ab2567
Source dataset
uspto-grants-1999_08
Patent number
US05942511

Reaction notes

Loading…