Allyl Mercaptan → 3-(2-Propoxy)-6-allylthiopyridazine

HRID 1585996Notes

Reaction equation

HRID 1585996 reaction equation
[Na].[CH2:2]([SH:5])[CH:3]=[CH2:4].[CH3:6][CH:7]([O:9][C:10]1[N:11]=[N:12][C:13](Cl)=[CH:14][CH:15]=1)[CH3:8]>CO>[CH3:6][CH:7]([O:9][C:10]1[N:11]=[N:12][C:13]([S:5][CH2:2][CH:3]=[CH2:4])=[CH:14][CH:15]=1)[CH3:8]

Participants

5

Reactant 3

HCID 13367Allyl MercaptanHCID 2528233-Chloro-6-isopropoxypyridazineHCID 5360545Sodium

Product 1

HCID 103982103-(2-Propoxy)-6-allylthiopyridazine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2.30 g(0.1 mol) of metallic sodium was dissolved in 150 ml of absolute methanol and then mixed with 9.28 ml(0.1 mol) of allylmercaptan. To this mixture was added 17.26 g(0.1 mol) of 3-(2-propoxy)-6-chloropyridazine. The reaction solution was refluxed for 24 hours and then treated according to the same manner as Example 1 to obtain the title compound as a pale yellow oil.

Workup

  1. temperatureThe reaction solution was refluxed for 24 hours
  2. additiontreated

Sources & evidence

ORD record
ord-6883f7ba025d416b87d303fd8434f977
Source dataset
uspto-grants-1999_08
Patent number
US05942511

Reaction notes

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