反应详情

温度

60 °C

To a solution of 2-hydroxy-3-nitrobenzaldehyde in DMF was added portionwise cesium carbonate (3 eq), followed by iodomethane (1.2 eq.). The solution was warmed to 60° C. for 2 hours, then cooled to room temperature and filtered. The filtrate was concentrated under vacuum and purified by column chromatography on SPE cartridge (Silica) using as eluent cyclohexane-ethyl acetate (8:2) to give the product in 72% yield.

1. temperaturecooled to room temperature
2. filtrationfiltered
3. concentrationThe filtrate was concentrated under vacuum
4. custompurified by column chromatography on SPE cartridge (Silica)
5. customto give the product in 72% yield