Hydrazine hydrate (1:1) → HCID 178478180, compound

HRID 1586353Notes

Reaction equation

HRID 1586353 reaction equation
O.[NH2:2]N.[Cl:4][C:5]1[CH:6]=[C:7]([C:12](=O)[CH:13]=[CH:14][N:15](C)C)[CH:8]=[C:9]([Cl:11])[CH:10]=1>C(O)C>[Cl:4][C:5]1[CH:6]=[C:7]([C:12]2[CH:13]=[CH:14][NH:15][N:2]=2)[CH:8]=[C:9]([Cl:11])[CH:10]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 70172352-Propen-1-one, 1-(3,5-dichlorophenyl)-3-(dimethylamino)-

Product 1

HCID 178478180HCID 178478180, compoundYield 90.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2.4 g (0.05 mol) of hydrazine hydrate are added slowly and at room temperature to a solution of 9 g (0.0369 mol) of 1-(3,5-dichlorophenyl)-3-dimethylamino-2-propen-1-one in 100 ml of ethanol. The reaction mixture is stirred for 2 hours at room temperature and then concentrated to dryness. The residue of triturated in heptane. 7.1 g (90% yield, melting point 156° C.) of 3-(3,5-dichlorophenyl)-1H-pyrazole are obtained.

Workup

  1. concentrationconcentrated to dryness
  2. customThe residue of triturated in heptane

Sources & evidence

ORD record
ord-d39b14f604524120bdb00888a635b751
Source dataset
uspto-grants-1999_08
Patent number
US05945382

Reaction notes

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