Sodium methanethiolate → 1-(3,5-Dichlorophenyl)-2-(methylthio)ethanone

HRID 1586365Notes

Reaction equation

HRID 1586365 reaction equation
[CH3:1][S-:2].[Na+].Br[CH2:5][C:6]([C:8]1[CH:13]=[C:12]([Cl:14])[CH:11]=[C:10]([Cl:15])[CH:9]=1)=[O:7]>CO>[Cl:15][C:10]1[CH:9]=[C:8]([C:6](=[O:7])[CH2:5][S:2][CH3:1])[CH:13]=[C:12]([Cl:14])[CH:11]=1

Participants

4

Reactant 2

HCID 4378561Sodium methanethiolateHCID 126224902-Bromo-1-(3,5-dichlorophenyl)ethan-1-one

Product 1

HCID 218526431-(3,5-Dichlorophenyl)-2-(methylthio)ethanoneYield 93.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

3.7 g (0.015 mol) of 1-(3,5-dichlorophenyl)-2-methylthio-1-ethanone are prepared by addition at 0° C. of 1.23 g (0.017 mol) of sodium methanethiolate in solution in 10 ml of methanol to 4.28 g (0.016 mol) of 2-bromo-1-(3,5-dichlorophenyl)-1-ethanone obtained above.

Workup

  1. customobtained above

Sources & evidence

ORD record
ord-267e4d7bd80c452e90d052f749abe405
Source dataset
uspto-grants-1999_08
Patent number
US05945382

Reaction notes

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