反应详情

0.15 ml of 1,8-diazabicyclo(5.4.0)undecen-7-ene is added, at room temperature, to a solution of 2.55 g (0.01 mol) of 4-chloro-3-(3,5-dichlorophenyl)pyrazole and 0.90 g (0.030 mol) of paraformaldehyde in 70 ml of THF. The reaction mixture is stirred for 4 h at room temperature. A solution of 1.20 g (0.015 mol) of acetyl chloride in 10 ml of THF is run in dropwise at 0° C. and stirring is continued for 6 h at room temperature. The reaction mixture is concentrated to dryness. The residue is taken up in 15 ml of heptane and then dried. We obtain 3.05 g of 1-acetoxymethyl-4-chloro-3-(3,5-dichlorophenyl)pyrazole, melting at 95° C.

1. customdropwise at 0° C.
2. stirringstirring
3. waitis continued for 6 h at room temperature
4. concentrationThe reaction mixture is concentrated to dryness
5. customdried