HCID 21852646, compound → HCID 21852652, compound

HRID 1586372Notes

Reaction equation

HRID 1586372 reaction equation
C([O:5][C:6]([CH2:8][N:9]1[CH:13]=[C:12]([Cl:14])[C:11]([C:15]2[CH:20]=[C:19]([Cl:21])[CH:18]=[C:17]([Cl:22])[CH:16]=2)=[N:10]1)=[O:7])(C)(C)C>FC(F)(F)C(O)=O>[C:6]([CH2:8][N:9]1[CH:13]=[C:12]([Cl:14])[C:11]([C:15]2[CH:20]=[C:19]([Cl:21])[CH:18]=[C:17]([Cl:22])[CH:16]=2)=[N:10]1)([OH:7])=[O:5]

Participants

3

Reactant 1

HCID 21852646HCID 21852646, compound

Product 1

HCID 21852652HCID 21852652, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of 6.85 g (0.0185 mol) of 1-t-butoxycarbonylmethyl-4-chloro-3-(3,5-dichlorophenyl)pyrazole in 100 ml of trifluoroacetic acid is stirred for 16 h at room temperature. The reaction mixture is poured onto 300 cm3 of an ice/water mixture. The insoluble material is recovered by filtration, washed with heptane and dried. We obtained 5.65 g of 1-carboxymethyl-4-chloro-3-(3,5-dichlorophenyl)pyrazole, melting at 182° C.

Workup

  1. filtrationThe insoluble material is recovered by filtration
  2. washwashed with heptane
  3. customdried

Sources & evidence

ORD record
ord-370d0049e14a40f5863593b457c478c1
Source dataset
uspto-grants-1999_08
Patent number
US05945382

Reaction notes

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