反应详情

温度

80 °C

20 g (0.5 mol) of NaOH are dissolved in 100 ml of water, and 38.2 g (0.2 mol) of 2,4-dichlorobenzoic acid, 22.5 g (0.3 mol) of glycine and 1.4 g (6 mmol) of basic copper carbonate are added. The mixture is heated to 80° C., and 28 g (0.2 mol) of potassium carbonate are added. It is heated at 100° C. for 3 h. The filtrate after filtration with suction while hot is added to 100 ml of water and adjusted to pH 1-2 with hydrochloric acid. The product then precipitates and is filtered with suction and dried. 41 g (0.18 mol; 89%) of N-carboxymethylene-4-chloroanthranilic acid are obtained.

1. temperatureIt is heated at 100° C. for 3 h
2. filtrationThe filtrate after filtration with suction
3. additionwhile hot is added to 100 ml of water
4. customThe product then precipitates
5. filtrationis filtered with suction
6. customdried