反应详情

A solution of 5-amino-4-carboxy-1-(2,2-diethoxyethyl)pyrazole (50 g) in 80% trifluoroacetic acid aqueous solution (250 ml) was stirred at room temperature for two days. The reaction mixture was evaporated in vacuo. The resultant solid was washed with cold water, collected by filtration and dried over phosphorus pentoxide in vacuo to give 7-carboxy-1H-imidazo[1,2-b]-pyrazole (17.10 g).

1. customThe reaction mixture was evaporated in vacuo
2. washThe resultant solid was washed with cold water
3. filtrationcollected by filtration
4. dry with materialdried over phosphorus pentoxide in vacuo