HCID 11139333, compound → HCID 178524811, compound

HRID 1586669Notes

Reaction equation

HRID 1586669 reaction equation
[NH2:1][C:2]1[N:6]([CH2:7][CH:8](OCC)OCC)[N:5]=[CH:4][C:3]=1[C:15]([OH:17])=[O:16]>FC(F)(F)C(O)=O>[C:15]([C:3]1[CH:4]=[N:5][N:6]2[CH:7]=[CH:8][NH:1][C:2]=12)([OH:17])=[O:16]

Participants

3

Reactant 1

HCID 11139333HCID 11139333, compound

Product 1

HCID 178524811HCID 178524811, compoundYield 55.1%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of 5-amino-4-carboxy-1-(2,2-diethoxyethyl)pyrazole (50 g) in 80% trifluoroacetic acid aqueous solution (250 ml) was stirred at room temperature for two days. The reaction mixture was evaporated in vacuo. The resultant solid was washed with cold water, collected by filtration and dried over phosphorus pentoxide in vacuo to give 7-carboxy-1H-imidazo[1,2-b]-pyrazole (17.10 g).

Workup

  1. customThe reaction mixture was evaporated in vacuo
  2. washThe resultant solid was washed with cold water
  3. filtrationcollected by filtration
  4. dry with materialdried over phosphorus pentoxide in vacuo

Sources & evidence

ORD record
ord-9e8c62e634824c829b20f2fe8c185c33
Source dataset
uspto-grants-1993_06
Patent number
US05215982

Reaction notes

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