Triethylamine → HCID 19759356, compound

HRID 1586806Notes

Reaction equation

HRID 1586806 reaction equation
[OH:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[C:13]([CH3:14])=[CH:12][CH:11]=[C:10]2[C:15]#[N:16])=[CH:5][CH:4]=1.C(N(CC)CC)C.[CH3:24][S:25](Cl)(=[O:27])=[O:26]>ClCCl>[CH3:24][S:25]([O:1][CH2:2][C:3]1[CH:4]=[CH:5][C:6]([N:9]2[C:13]([CH3:14])=[CH:12][CH:11]=[C:10]2[C:15]#[N:16])=[CH:7][CH:8]=1)(=[O:27])=[O:26]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 19759404HCID 19759404, compound

Product 1

HCID 19759356HCID 19759356, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Conditions

Temperature
0 °C

Procedure

To a solution of 1-(4-hydroxymethylphenyl)-5-methylpyrrole-2-carbonitrile (890 mg) in dichloromethane (9 ml) was added triethylamine (794 μl) and methanesulfonyl chloride (343 μl) at 0° C. under nitrogen atmosphere. The mixture was stirred at 0° C. for an hour and then dichloromethane was added therein. The mixture was stirred and washed with water twice and brine, dried over magnesium sulfate and concentrated in vacuo to give 1-(4-methanesulfonyloxymethylphenyl)-5-methylpyrrole-2-carbonitrile (1.19 g).

Workup

  1. stirringThe mixture was stirred
  2. washwashed with water twice
  3. dry with materialbrine, dried over magnesium sulfate
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-5c5f7b06ad8c45ab8a842658931ea5c1
Source dataset
uspto-grants-1993_06
Patent number
US05215994

Reaction notes

Loading…